Electron Transfer Flavoprotein Subunit Beta is Involved in Behcet’s Disease
نویسندگان
چکیده
This article aim to make a comment on the previous study published entitled “electron transfer flavoprotein subunit beta (ETFB) is a candidate endothelial cell autoantigen in Behcet’s Disease (BD)”. Recently, serum IgG levels of anti-ETFB in BD patients from Shanxi Dayi Hospital were evaluated. The level of IgA against ETFB was also measured in Intestinal Behcet's disease. In addition, correlation of human ETFB, HSP60 and hnRNP-A2/B1 was analyzed. This result verified our previous conclusion. We also discovered that ETFB might be related with mucosal immune, and the pathology of intestinal BD may be related with the infection of intestinal microorganism.
منابع مشابه
Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behçet’s Disease
Behçet's disease (BD) is a chronic inflammatory disease with multisystem involvement, and it is listed as a rare disease in the United States but is common in the Middle East, China, and Japan. The aim of this study was to identify novel autoantigens in Chinese patients with BD. First, the candidate autoantigens were screened by Western blotting, and the sequences of putative antigens were iden...
متن کاملLack of allosterically controlled intramolecular transfer of nitric oxide from the heme to cysteine in the beta subunit of hemoglobin.
The SNO-Hb hypothesis holds that heme-bound nitric oxide (NO) present in the beta subunits of T-state hemoglobin (Hb) will be transferred to the beta-93 cysteine upon conversion to R-state Hb, thereby forming SNO-Hb. A deficiency in the ability of Hb to facilitate this intramolecular transfer has recently been purported to play a role in pulmonary hypertension and sickle cell disease. We prepar...
متن کاملSubunit structure of electron transfer flavoprotein.
The electron transfer flavoprotein from pig liver mitochondria is a 57,000-dalton electron transferase which links several primary flavoprotein dehydrogenases with the mitochondrial electron transport system. The protein was previously reported to be a dimer of apparently identical subunits. There are conflicting estimates in the literature regarding the FAD content of the protein. The results ...
متن کاملRole of flavinylation in a mild variant of multiple acyl-CoA dehydrogenation deficiency: a molecular rationale for the effects of riboflavin supplementation.
Mutations in the genes encoding the alpha-subunit and beta-subunit of the mitochondrial electron transfer flavoprotein (ETF) and the electron transfer flavoprotein:ubiquinone oxidoreductase (ETF:QO) cause multiple acyl-CoA dehydrogenation deficiency (MADD), a disorder of fatty acid and amino acid metabolism. Point mutations in ETF, which may compromise folding, and/or activity, are associated w...
متن کاملA new iron-sulfur flavoprotein of the respiratory chain. A component of the fatty acid beta oxidation pathway.
The iron-sulfur (Fe-S) flavoprotein from beef heart mitochondria previously reported (Ruzicka, F. J., and Beinert, H. (1975) Biochem. Biophys. Res. Commun. 66, 622-631) has been purified to apparent homogeneity by the criteria of polyacrylamide electrophoresis. The purity has been increased 3to 4-fold over that achieved previously with no major change in the observed properties. The protein con...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016